Acetaminophen intoxication Tylenol overdose

Acetaminophen intoxication
  • History / PE:
    Nausea, vomiting , anorexia (early stage)
  • Treatment:
    1) Within four hours of ingestion, administer activated charcoal

    2) Check serum levels at 4 hour mark (first data/decision point)

    3) Refer to Rumack-Matthew normogram (provides likelihood of hepatotoxic effects of acetaminophen OD based on plasma levels and hours after ingestion)

    4) Administer N-acteylcysteine / mucomyst as appropriate (can be administered within 8 hrs of ingestion without affecting outcome)

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July 30th 2010