Myeloblasts on peripheral smear
Periodic acid Schiff (PAS) positive material
Terminal deoxynucleotidyltransferase (TdT) positive (expressed on pre B and pre T lymphoblasts)
AML type M3 (acute promyelocytic leukemia)
Auer rods present
Good prognosis, responsive to all-trans-retinoic acid (ATRA)
**Associated with DIC**
AML type M5 (acute monocytic leukemia)
Monoblasts lack Auer rods
HAs, fever, weight loss
Gingival hyperplasia and occasional skin lesions
Positive alpha-naphthyl esterase positive test
Poor prognosis CD 34+ or MDR1+
Elevated LDH
FLT3 gene mutation
AML type M7 (acute megakaryocytic variant)
