DMARDs Disease-modifying antirheumatic drugs

  • Facts:
    1) Methotrexate (1st line, dihydrofolate reductase inhibitor)
    2) Hydroxychloroquine
    3) Sulfasalazine
    4) Etanercept
    5) Azathioprine
    6) Leflunomide
  • Indications:
    Rheumatoid arthritis (initiate treatment as soon as diagnosis is made)
  • Side Effects:
    Methotrexate
    Macrocytic anemia
    Alopecia
    Hepatotoxicity
    Interstitial lung disease

    Hydroxycholoroquine
    VIsual disturbances
    Hemolysis in G6PD
    GI distress



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August 5th 2010