Factor V Leiden

• Facts:
  MC inherited disorder causing hypercoagulability and predisposition to thrombus, especially DVT of the lower extremities
  
  Result of a point mutation in gene encoding for the coagulation factor V
  
  Factor V becomes resistant to inactivation by protein C
• History / PE:
  Recurrent thrombotic complications
  Recurrent miscarriages (women)
• Differential Diagnosis:
  Protein C deficiency
  Protein S deficiency
  Antithrombin III deficiency
  Hyperhomocysteinemia
  Antiphospholipid syndrome (acquired)