Hairy cell leukemia
HCL
Facts
:
Malignant disorder of well-differentiated B lymphocytes
MC affects older males
History / PE
:
Weakness
Fatigue
Easy brusing
Splenomegaly
Diagnosis
:
Bone marrow becomes fibrotic (dry tap)
Tartrate-resistant acid phosphatase
(TRAP) staining
Leukopenia
CD 11c marker
Fine, hair-like irregular projections from lymphocytes
Treatment
:
Nucleoside analogs (eg. cladribine)
See Also
:
White blood cell disorders
Associated With
:
Mycobacterium avium-intracellulare
July 24th 2010
Categories
Hematology
Internal Medicine
Links
Files & Images
Blood smear