Hodgkin's lymphoma

• Facts:
  Predominantly B cell malignancy of unclear etiology
  Bimodal age distribution, MC in men
• History / PE:
  Cervical, mediastinal lymphadenopathy
  Pel-Ebstein fevers (1-2 wks high fever, then 1-2wks afebrile)
  Mediastinal mass
  Systemic B symptoms
  Pruritis
  Heaptosplenomegaly
  
• Diagnosis:
  Excisional lymph node biopsy
  Reed-Sternberg cells ("Owl-eyes")
  Hypercalcemia (from calcitriol)
• Treatment:
  1) Radiation
  2) Adriamycin, bleomycin, vinblastine, decarbazine [ABVD]
  3) Mechlorethamine, oncovin (vincristine), procarbazine, and prednisone [MOPP]
• Notes:
  Lymphadenopathy becomes more painful with ETOH consumption
• See Also:
  White blood cell disorders
• Associated With:
  EBV ( Burkitt lymphoma )
  Minimal change disease