Intrahepatic cholestasis of pregnancy ICP

• Facts:
  Functional disorder of bile formation that develops in the second and third trimester of pregnancy
• History / PE:
  Intense pruritis
  Skin excoriations
  Jaundice
  
• Diagnosis:
  Elevated serum aminotransferases
• Treatment:
  Symptom relief (ursodeoxycholic acid)
  Early delivery (after lung maturity)
  Condition resolves soon after delivery
• Complications:
  Fetal prematurity
  Intrauterine demise
• Differential Diagnosis:
  Acute fatty liver of pregnancy (no jaundice)
  Primary sclerosing cholangitis
  Primary biliary cirrhosis