Macrolides

• Facts:
  Generally good G+ coverage
  Atypical pneumonias (Mycoplasma, Legionella, Chlamydia )
  Ear/sinus infections
  Poor G- coverage
• Indications:
  1) Azithromycin (Zithromax)
  2) Clarithomycin (Biaxin, metallic taste)
  3) Clindamycin (Cleocin)
  4) Erythromycin (stomach upset)
• Side Effects:
  Ototoxicity
  QT prolongation
• Notes:
  Interacts with statins (increase chance of rhabdomyolysis) and fluconazole
• See Also:
  Antibiotics