McCune-Albright syndrome

• Facts:
  Defect in the G-protein cAMP-kinase function
• History / PE:
  Bone fractures
  Irregular, light brown "spots"
  Early puberty
• Pneumonic:
  3 P's
  
  Precocious puberty
  Pigmentation (cafe au lait spots)
  Polyostotic fibrous dysplasia
• See Also:
  Neurofibromatosis type 1
• Associated With:
  Hyperthyroidism
  Adrenal hypercortisolism