Osteogenesis imperfecta Brittle bone disease

• Facts:
  Autosomal dominant disease
  Defect in type 1 collagen synthesis
  Four different types (type 2 is most severe, die in utero)
• History / PE:
  Blue sclerae
  Limb deformities
  Multiple fractures
  Growth retardation, scoliosis
• Associated With:
  Dentinogenesis imperfecta (discolored, translucent, weak teeth)
  Hearing loss