Serum sickness-like reaction

Serum sickness-like reaction
  • Facts:
    Most commonly occurs in kids following the treatment of viral infections with antibiotic agents

    Hypersensitivity-like reaction that occurs one to two weeks after administration of certain drugs (eg. cefaclor, penicillin, amoxicillin, bactrim )
  • History / PE:
    Fever, arthralgias
  • Diagnosis:
    Clinical diagnosis
  • Treatment:
    Withdraw offending agent
  • Notes:
    Does NOT represent a true drug allergy

    Condition derives name from similarities to true serum sickness (immune-complex mediated hypersensitivity reaction to human proteins)
  • See Also:
    Arthus reaction
  • Associated With:
    Type 3 hypersensitivity reaction

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August 10th 2010