VIPoma Verner Morrison syndrome

  • Facts:
    Rare endocrine tumor,usually (about 90%) originating in the pancreas, that produces vasoactive intestinal peptide (VIP)

    Massive amounts of VIP in turn cause profound and chronic watery diarrhea with resultant dehydration, hypokalemia , achlorhydria (hence WDHA-syndrome, or pancreatic cholera syndrome)
  • History / PE:
    W atery D iarrhea
    H ypokalemia
    A chlorhydria

    Lethargy, muscle weakness
    Abdominal pain, cramping
  • Diagnosis:
    Elevated vasoactive intestinal peptide (VIP) in the blood
  • Associated With:
    MEN I



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August 4th 2010