Zollinger-Ellison syndrome ZES

Zollinger-Ellison syndrome
  • Facts:
    MCC is gastrin-producing pancreatic tumor (gastrinoma)
    Uncontrolled gastrin production leads to parietal cell hyperplasia
    Parietal cells produces tons of acid
  • History / PE:
    Severe, refractory PUD
    Jejunal ulcers (pathognomonic)
    Impaired fat absorption
    Prominent gastric folds
  • Diagnosis:
    Fasting serum gastrin > 1000 pg/ml
    Secretin stimulation test
  • Associated With:
    MEN I
    Pancreatic malabsorption (pancreatic enzyme inactivation)

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July 23rd 2010