Acute febrile nonhemolytic transfusion reaction AFNTR

• Facts:
  Antibodies in the patient's plasma react with donor leukocytes causing activation of complement components and release of inflammatory cytokines
  
• History / PE:
  Fever and chills during or within a few hours of transfusion completion
• Treatment:
  NSAIDs
  Acetaminophen
• Notes:
  Leukocyte depletion techniques can reduce probability (eg. cell washing)
  
• Differential Diagnosis:
  Urinary tract infection
  Drug fever