Dubin-Johnson syndrome

• Facts:
  Benign condition
  Conjugated, chronic hyperbilirubinemia
  
• History / PE:
  Icterus
  Fatigue
  Abdominal pain
• Diagnosis:
  Dark granular pigment within hepatocytes
  Normal total urinary coproporphyrin (80% coproporyphrin I)
  Grossly black liver
• Treatment:
  None required
• See Also:
  Isolated hyperbilirubinemia
• Differential Diagnosis:
  Rotor syndrome (defect in hepatic storage, leakage into plasma)