Hemolytic uremic syndrome HUS

• Facts:
  A type of microangiopathic hemolytic anemia
  
  Typically a disease of young children, usually follows recent diarrheal illness due o the pathogens E.coli, serotype 0157:H7, Shigella, Salmonella, Yersina, and Campylobacter species
  
  Classic triad of hemolytic anemia , ARF, and thrombocytopenia
  
• History / PE:
  Bloody diarrhea
  Sudden onset abdominal pain
  Purpura / petchiae
  Hypertension
  GI bleeding
• Diagnosis:
  Schistocytes and giant platelets (blood smear)
  Markedly elevated BUN and creatinine
  Moderate leukocytosis
• See Also:
  1) TTP (HUS triad plus fever and neurologic changes)
  2) HELLP (found in pregnant women)
  3) ITP (isolated thrombocytopenia)
  4) DIC (abnormal clotting factors)