Hereditary non-polyposis colorectal cancer (HNPCC) Lynch syndrome

• Facts:
  Divided into two subgroups based on clinical grounds,
  
  Hereditary site specific colon cancer (Lynch syndrome I)
  Cancer family syndrome (Lynch syndrome II)
• Diagnosis:
  1) At least three relatives with colorectal cancer, one of whom must be a first-degree relative of the other two
  2) Involvement of two or more generations
  3) At least one case diagnosed before age 50
  4) Familial adenomatosus polyposis has been excluded
• Associated With:
  1) Endometrial cancer (Lynch syndrome II)
  2) Turcot's syndrome (HNPCC and gliomas)