Hereditary telangiectasia Osler-Weber-Randu Syndrome

• Facts:
  Autosomal dominant disease
  Abnormal blood vessel formation
  
• History / PE:
  Recurrent nose bleeds
  Oral lesions
  Diffuse telangiectasias
  Digital clubbing
• Diagnosis:
  AVMs in skin, mucous membranes, GI tract
• Notes:
  AVM's in lung can shunt blood from R to L, causing hypoxemia, and a reactive polycythemia
• Differential Diagnosis:
  Polycythemia vera