Huntington's disease

• Facts:
  Autosomal dominant (defect on Ch. 4), affects both sexes equally
  Striatal neurodegeneration
  Typically presents between 30 - 50 years old
• History / PE:
  Choreiform movements
  Early onset dementia
  Family history
  Progressive intellectual deterioration
  Psychiatric (mood) disturbances
• Diagnosis:
  Atrophy of caudate nucleus
• Treatment:
  Supportive