Idiopathic pulmonary fibrosis IPF

• Facts:
  Restrictive lung disease
  Chronic inflammation of the alveolar walls causes widespread fibrosis and destruction of the normal lung architecture
• History / PE:
  Rapid, shallow breathing
  Chronic dyspnea
  Nonproductive cough
  Digital clubbing
  Dry, end-expiratory crackles
• Diagnosis:
  Normal FEV1/FVC
  Decreased TLC
  Increased A-a gradient
  Honeycombing on CXTR
• Associated With:
  Radiation
  Drugs (busulfan, nitrofurantoin, amiodarone , bleomycin)
  Long term high oxygen-from ventilator use
  Pneumocossis
  Hypersensitivity syndromes
  Granulomatous disorders