Mixed connective tissue disease Sharp's syndrome

• Facts:
  Autoimmune, connective tissue disease (no RENAL involvement)
  
  Considered an overlap syndrome because it combines features of scleroderma , myositis, systemic lupus erythematosus , and rheumatoid arthritis ( with some sources adding polymyositis , dermatomyositis , and inclusion body myositis )
• History / PE:
  Joint pain/swelling
  Malaise
  Arthralgias
  Muscle inflammation
  Sclerodactyly
• Diagnosis:
  Anti-nRNP (nuclear ribonucleoprotein) positive
• Associated With:
  HLA-DR4