Mononucleosis Mono

• Facts:
  Acute, benign, self limited disease caused by EBV
• History / PE:
  Fatigue/malaise
  Sore throat
  Splenomegaly
  Posterior cervical lymphadenopathy
  Palatal petechiae
• Diagnosis:
  Heterophile antibodies (monospot)
  Atypical lymphocytes on smear
• Complications:
  Autoimmune hemolytic anemia and thrombocytopenia
  Splenic rupture
• Notes:
  Monospot test may be falsely negative early in mono
  
  Patients can resume normal activity when spleen no longer palpable (usually 1-3 months)
• Differential Diagnosis:
  Acute pharyngitis
  CMV mononucleosis (no pharyngitis)