Neuroblastoma

• Facts:
  Most common extracranial tumor of childhood
  Median age of diagnosis is 2 years
  Arises from neural crest cells
  
• History / PE:
  Fever, weight loss
  Hepatomegaly
  Abdominal mass that crosses the midline
• Diagnosis:
  Urinary catecholamine metabolites (VMA, HVA)
  Calcifications and hemorrhage (xray/CT)
  
• Differential Diagnosis:
  Wilms' tumor (arises from metanephros, bilateral)