Primary sclerosing cholangitis PSC

• Facts:
  Inflammation and fibrosis of the intra and extra hepatic ducts
• History / PE:
  Fatigue
  Pruritis
  
• Diagnosis:
  Elevated alkaline phosphatase and bilirubin
  "Beading" of the bile ducts (cholangiography)
  p-ANCA
• Complications:
  ESLD
  Portal HTN
  Biliary stricture
  Cholangiocarcimona
• See Also:
  Primary biliary cirrhosis
• Associated With:
  Ulcerative colitis