Reye syndrome Fatty liver with encephalopathy

• Facts:
  Children ( < 15 years old ) treated with ASA for viral fever
  Characterized by diffuse mitochondrial injury
  Mortality rate 30-35%
• History / PE:
  Vomiting
  Agitation
  Lethargy
  Restlessness
• Diagnosis:
  Hyperammonemia
  Prolonged PT
  Hypoglycemia
  Extensive fatty vacuolization of liver
• Treatment:
  Glucose with FFP
  Mannitol (decrease cerebral edema)
• Complications:
  Fulminant hepatic failure
• Associated With:
  Aspirin