Sepsis

Microbial invasion or toxins in bloodstream

• Facts:
  SIRS criteria
  Temperature <36 C or > 38 C
  Tachypnea >20 bpm or PaCO2 < 32mmHg on ABG
  
• Treatment:
  Maintain BP and perfusion
  IVF, pressors, and empiric ABx
• Notes:
  1. SIRS (2/4 of criteria)
  2. Sepsis (SIRS plus identified source)
  3. Severe sepsis (oliguria)
  4. Septic shock (hypotension or end organ failure)