Serum sickness-like reaction

• Facts:
  Most commonly occurs in kids following the treatment of viral infections with antibiotic agents
  
  Hypersensitivity-like reaction that occurs one to two weeks after administration of certain drugs (eg. cefaclor, penicillin, amoxicillin, bactrim )
  
• History / PE:
  Fever, arthralgias
  Urticaria
  Lymphadenopathy
  Proteinuria
• Diagnosis:
  Clinical diagnosis
• Treatment:
  Withdraw offending agent
• Notes:
  Does NOT represent a true drug allergy
  
  Condition derives name from similarities to true serum sickness (immune-complex mediated hypersensitivity reaction to human proteins)
• See Also:
  Arthus reaction
• Associated With:
  Type 3 hypersensitivity reaction