Stevens Johnson syndrome Erythema multiforme major

• Facts:
  Usually drug induced
  Exfoliative mucocutaneous disease
  Involves immune complex mediated hypersensitivity
  
• History / PE:
  1) Degeneration of the basal layer of the epidermis
  2) Target shaped, mucocutaneous lesions
  3) Signs of systemic toxicity (fever, hypotension, AMS, conjunctivitis, seizures, coma)
• Diagnosis:
  Less than 10% of body surface area involved
  
• Associated With:
  NNRTIs( HIV therapy )
  Penicillin
  Sulfonamides
  Seizure medications (eg. phenytoin )
• Differential Diagnosis:
  Staphylococcal scalded-skin syndrome
  Erythema multiforme
  Toxic epidermal necrolysis