Toxoplasmosis Toxoplasma gondii

• Diagnosis:
  Serology, PCR
  Multiple ring enhancing lesions on CT
  Predilection for basal ganglia
• Treatment:
  Prophylaxis
  Bactirm
  
  Induction
  High dose pyrimethamine + sulfadiazine and leukovorin X 4-8 weeks
  
  Maintenance
  Low dose pyrimethamine + sulfadiazine and leukovorin until resolution
• Associated With:
  AIDS
  Immunocompromised patients
• Differential Diagnosis:
  CNS lymphoma (EBV DNA in CSF, solitary, weakly ring-enhancing periventricular mass)
• Risk Factors:
  Ingesting raw or undercooked meat
  Changing cat litter