TCA OD causes inhibition of cardiac fast sodium channels (QRS prolongation)
Treat OD with sodium bicarbonate (helps correct acidosis AND narrow QRS prolongation)
Indications:
Depression
Insomnia
Notes:
Overdose causes hyperthermia, seizures, hypotension, and anticholinergic effects. Decreased myocardial conduction velocity, leads to QRS prolongation; EKG is the best test to predict of the extent of TCA OD (QRS duration)
