Cephalosporins

• Facts:
  Inhibit cell wall synthesis
  Generally, less susceptible to penicillinases
• Indications:
  First generation (fad, faz, phal)
  Covers G+, PEcK
  *Proteus, E. coli, Klebsiella
  
  1) Cefadoxil (Duricef)
  2) Cefazolin (Ancef)
  3) Cephalexin (Keflex, 1st line for cellulitis )
  
  Second generation (fac, fox, fur)
  Covers G+, HEN PEcK (more -, less +)
  *H. Influ, Enterobact, Neisseria
  
  1) Cefaclor
  2) Cefoxitin (abdominal infxn, peritonitis)
  3) Cefuroxime (CAP)
  
  Third generation (Crosses BBB)
  Covers serious G-, meningitis , Lyme, some pseudomonal coverage
  
  1) CefTAZidime
  2) CeftizOXime
  3) CefpodOXime (Vantin)
  4) CefoTAXime
  5) CefOPERAZONE (Cefobid)
  6) CefTRIAXONE (Rocephin)
  7) CeFIXime (Suprax)-oral
  8) CefDINIR (Omnicef)
  
  Fourth generation
  Covers Pseudomonas, MSSA
  
  1) Cefipime (Maxipime)
  
  Fifth generation
  
  1) Ceftobiprole