Churg-Strauss syndrome Allergic granulomatosis

• Facts:
  Medium and small vessel autoimmune vasculitis that leads to necrosis
  
  Involves mainly the blood vessels of the lungs (it begins as a severe type of asthma ), gastrointestinal system, and peripheral nerves
  
  Also affects the heart, skin and kidneys
• History / PE:
  Allergies
  Asthma
• Diagnosis:
  Eosinophil granulocytes
  Perinuclear pattern of antineutrophil cytoplasmic (p-ANCA) antibodies
• Treatment:
  Corticosteroids (eg. prednisolone)
• Differential Diagnosis:
  Polyarteritis nodosa
  Wegener's granulomatosis (c-ANCA)