Disseminated intravascular coagulation Consumptive coagulopathy

• Facts:
  Pathological activation of clotting factors, that leads to the formation of small blood clots within the blood vessels
• History / PE:
  Extensive bleeding (from venipuncture site, surgical wounds)
  Renal failure
• Diagnosis:
  Prolonged PT, PTT
  Increased in fibrin split products (d-dimer)
  Decreased hematocrit, platelets
• Treatment:
  Underlying pathology/disorder
  Platelet transfusion, cryoprecipitate (coagulopathy)
  Aminocaproic acid (second line)
• Associated With:
  1) Pregnancy ( placental abruption , amniotic fluid embolism)
  2) Major trauma / burns
  3) Sepsis
  4) Malignancy