Drug overdoses

• Facts:
  Aspirin
  Tinnitus, hypogylcemia, vomiting
  Metabolic acidosis and a respiratory alkalosis
  Treat by alkalinization of urine with bicarbonate
  
  Tricyclic antidepresssants
  Treat with sodium bicarbonate
  
  Tylenol
  Treat with N-acetelycystein (mucomyst)
  
  Benzodiazepines
  Slurred speech, unsteady gait, normal pupil size
  Treat with flumazenil
  
  Opioid
  Respiratory depression, meiosis, sedation
  Treat with naloxone
  
  Lithium
  Tremor, hypereflexia, ataxia, seizures
  Treat with hemodialysis
  
  Phenytoin
  Horizontal nystagmus, cerebellar ataxia, confusion
  
  Beta blockers
  AV block, hypotension, diffuse wheezing, bradycardia
  Treat with atropine and IVF (glucagon as 2nd line)
  
  Digoxin
  Blurred vision, disturbed color preception, fatigue, HAs
  Bradycardia, AV block, hypotension, but NO wheezing!
  Treat with digoxin specific antibody
  
  Iron overdose
  Radioopaque tablets in stomach
  Abdominal pain, hematemsis, metabolic acidosis
  Treat with deferoxamine
  
  Cocaine intoxication
  Excruciating chest pain, atrophic nasal mucosa
  Complications include cardiac ischemia/infarction
  Treat with benzos, ASA, nitrates
  
  Diphenhydramine poisoing
  Anticholinergic symptoms, drowsiness, confusion
  Treat with physostigmine (cholinesterase inhibitor)
  
  Vitamin D toxicity
  Hypercalcemia , constipation , abdominal pain, weight loss, polyuria, polydispsia
  Treat by withholding calcium and vitamin D until symptoms resolve