Goodpasture's syndrome

• Facts:
  Anti-GBH glomerulonephritis ( nephritic syndrome )
  Rapidly progressing disease with pulmonary hemorrhage
  Peak incidence is males in mid 20s
• History / PE:
  Hemoptysis
  Dyspnea
  Possible respiratory failure
• Diagnosis:
  Iron deficiency anemia
  Linear anti-GBM deposits (immunofluorescence)
  Hemosiderin-filled macrophages
  Pulmonary infiltrates (CXR)
• Treatment:
  Emergency plasmapheresis
  Pulsed steroids
• Complications:
  ESRD
• See Also:
  Nephrotic syndrome
• Differential Diagnosis:
  Wegener's granulomatosis (c-ANCA, no linear anti-GBM deposits)