Lambert-Eaton syndrome

• Facts:
  Results from autoantibodies against the voltage-gated calcium channels in the presynaptic motor nerve terminal
  
  Leads to impaired release of ACH from presynaptic cleft
  
  Paraneoplastic syndrome ( small cell lung carcinoma )
  
• History / PE:
  Muscle weakness (extraocular muscle sparing)
• See Also:
  Myasthenia gravis
• Associated With:
  Small cell lung cancer
• Differential Diagnosis:
  Organophosphate poisoning
  High doses of aminoglycosides