Myasthenia gravis MG

• Facts:
  Autoimmune destruction of post synaptic ACH receptors
• History / PE:
  Ptosis
  Double vision
  Muscle fatigability
• Diagnosis:
  EMG
  Acetycholine receptor Ab
  Edrophonium (tensilon) test (improves muscle weakness)
  Chest CT (looking for thymoma)
• Treatment:
  Long-acting anticholinesterase (pyridostigmine, neostigmine)
  Plasmapheresis (acute severe crisis)
• Complications:
  Myasthenia crisis (marked respiratory weakness)
• See Also:
  Lambert-Eaton syndrome
• Associated With:
  Thymomas
• Differential Diagnosis:
  Organophosphate poisoning
  High doses of aminoglycosides