Mononucleosis Mono

  • Facts:
    Acute, benign, self limited disease caused by EBV
  • History / PE:
    Sore throat
    Posterior cervical lymphadenopathy
    Palatal petechiae
  • Diagnosis:
    Heterophile antibodies (monospot)
    Atypical lymphocytes on smear
  • Complications:
    Autoimmune hemolytic anemia and thrombocytopenia
    Splenic rupture
  • Notes:
    Monospot test may be falsely negative early in mono

    Patients can resume normal activity when spleen no longer palpable (usually 1-3 months)
  • Differential Diagnosis:
    Acute pharyngitis
    CMV mononucleosis (no pharyngitis)

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August 4th 2010