Multiple sclerosis MS

• History / PE:
  Optic neuritis
  Internuclear ophthalmoplegia (demyelination of MLF)
  Nystagmus
  Scanning speech
  L'Hermitte's sign
• Diagnosis:
  Asymmetric, periventricular lesions on MRI (Dawson's fingers)
  Oligoclonal bands (CSF)
• Treatment:
  IV steroids (exacerbations)
  Beta-interferon (avonex, betaseron)
  Copaxone (glatiramer)
• Notes:
  Relapsing/remitting has best prognosis