Polycystic kidney disease PKD

• Facts:
  Autosomal dominant (ADPKD)
  MC; usually asymptomatic until > 30 yo
  
  Autosomal recessive (ARPKD)
  Less common, more severe; in infants and young children
• History / PE:
  Pain, hematuria
  HTN
  Palpable kidneys
• Diagnosis:
  U/S or CT scan
  Genetic testing ADPKD1 and ADPKD2
• Treatment:
  Prevent complications
  Decrease rate of progression to ESRD
  ACEIs, ARBs (BP control)
• Notes:
  Easier to feel R kidney because it lies lower than L kidney
• Associated With:
  1) Intracranial berry aneurysms
  2) Hepatic cysts (MC extra-renal complication)
  3) Valvular heart disease (MVP and AR)
  4) Nephrolithiasis
  5) HTN
  6) Colonic diverticula
  7) Abdominal wall and inguinal hernia
• Differential Diagnosis:
  Renal cell carcinoma
  Bladder cancer