Renal amyloidosis

• Facts:
  Nephrotic syndrome
  Primary (plasma cell dyscrasia)
  Secondary (infectious or inflammatory)
• Diagnosis:
  Nodular glomerulosclerosis
  Apple-green birefringence with Congo red stain
  EM reveals amyloid fibrils
• Treatment:
  Prednisone and melphalan
  Bone marrow transplant ( multiple myeloma )
• See Also:
  Amyloidosis
• Associated With:
  Multiple myeloma
  Chronic inflammatory disease (eg. RA, TB)