Rheumatic fever

  • Facts:
    Complication of group A Streptococcal pharyngitis (usually precedes RF by 2-4wks)

    Prevented by proper treatment of Streptococcal pharyngitis

    RH disease caused by antistreptococcal antibodies cross-reacting with a cardiac antigen ( type 2 hypersensitivity reaction )
  • History / PE:
    Diagnosed clinically by using JONES criteria
  • Diagnosis:
    Evidence of preceding strep infection, plus EITHER
    two major criteria or one major AND two minor criteria

    Elevated antistreptolysin antibodies (ASO), DNAse B
  • Notes:

    1) Carditis
    2) Sydenham chorea
    3) Migratory polyarthritis
    4) Subcutaneous nodules
    5) Erythema marginatum


    1) Arthralgia
    2) Fever
    3) Elevated ESR/C reactive protein
    4) Prolonged PR interval
  • Associated With:
    Scarlet fever

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August 9th 2010