RTA type IV Distal, hyperkalemic

• Facts:
  Aldosterone deficiency/resistance
  Leading to defects in sodium absorption and hydrogen/potassium excretion
• Diagnosis:
  Hyperkalemia , hyperchloremic acidosis
  Non-ionic gap metabolic acidosis
  
• Treatment:
  Furosemide
  Mineralocorticoid +/- glucocorticoid replacement
  Low potassum diet in patients with aldosterone deficiency
• See Also:
  Renal tubular acidosis
• Associated With:
  1) Diabetes mellitus
  2) Obstructive uropathy and renal disease (in children)
  3) Primary aldosterone deficiency
  4) Hyporeninemic hypoaldosteronism (eg. kidney disease, ACEIs, NSAIDs )
  5) Drugs (eg. amiloride, spironolactone , heparin )
  6) Pseudohypoaldosteronism