Angioedema

AngioedemaAngioedema
  • Facts:
    Self-limited,localized swelling of the skin or mucosal tissues, which results from extravasation of fluid into the interstitum due to loss of vascular integrity

    Mast cell-mediated (urticaria, pruritis)
    Direct mast cell release
    Allergic reactions
    ASA, NSAIDs
    Chronic urticaria w/ or w/o angioedema

    Bradykinin mediated (no pruritis, no urticaria)
    ACEIs, ARBs
    Hereditary and acquired angioedema
    Estrogens

    Unknown etiologies
    Calcium channel blockers
    Fibrinolytic agents (eg. alteplase)
  • History / PE:
    Cutaneous edema (face, limbs, genitalia)
    Laryngeal edema
    Abdominal edema(colicky abdominal pain)
  • Diagnosis:
    Trypase levels (mast cell mediated) w/i 6-12 hrs of symptom onset
  • Treatment:
    Antihistamines, steroids
  • Notes:

  • See Also:
    Hereditary and acquired angioedema
  • Differential Diagnosis:
    Cellulis, erysipelas
    Facial lymphedema
    SVC syndrome
    Blepharochalasis (repeated swelling of eyelids)
    Autoimmune disorders (eg. SLE, lupus)
    Parasitic infections



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September 8th 2010