Hereditary and acquired angioedema

• Facts:
  Pathology of both forms involve C1 inhibitor deficiency, dysfunction, or destruction
  
  Hereditary
  Presents in late childhood, usually follows an infection, dental procedure, or trauma
  Normal C1q levels
  
  Acquired
  MCC is ACEI use
  Depressed C1q levels
  
  C1 esterase inhibitor deficiency leads to elevated levels of C2b and bradykinin (edema-producing factors)
• Diagnosis:
  C1 esterase inhibitor deficiency
  Depressed C4 levels in both forms
• Treatment:
  Hereditary angioedema
  C1 inhibitor concentrate, Kallikrein inhiitor, FFP
• See Also:
  Angioedema