Diabetes mellitus type 1 DM I

• Facts:
  From autoimmune pancreatic beta cell destruction
• History / PE:
  Polydipsia
  Polyphagia
  Unexplained weight loss
  Ketoacidosis
• Diagnosis:
  1.) Fasting plasma glucose >126mg/dL on two occasions OR
  
  2.) Random plasma glucose > 200 mg/dL plus symptoms OR
  
  3.) Two-hour postprandial glucose > 200 mg/dL after a glucose tolerance test on 2 separate occasions
• Treatment:
  Insulin
  
  Management
  Routine HbA1C testing
  BP checks
  Foot checks
  Annual dilated-eye exams
  Annual microalbuminuria screening
  Lipid profile q 2-5 years
• Complications:
  RTA type IV
  Diabetic ketoacidosis
  Diabetic nephropathy
  Diabetic neuropathy
  Overflow incontinence (detrusor weakness)
• See Also:
  Diabetes mellitus type 2
• Associated With:
  HLA-DR3 /-DR4
  Dawn phenomenon
  Somogyi effect