Non-Hodgkin's lymphoma NHL

• Facts:
  Progressive clonal expansion of B cells, T cells, NK cells
  
  1.) Stimulated by chromosomal translocations, MC is t (14, 18)
  2.) Inactivation of tumor suppressor genes
  3.) Introduction of exogenous genes by oncogenic viruses (eg. EBV, HTLV-1, HCV)
• History / PE:
  More common in women ( HD more common in men)
  Systemic adenopathy
• Diagnosis:
  Excisional lymph node biopsy
  Disease staging (Ann Arbor classification)
• Treatment:
  Cyclophosphamide (cytoxan), adriamycin, oncovin (voncristine), and prednisone [CHOP]
• Complications:
  Tumor lysis syndrome
• Notes:
  5 times MC than Hodgkin's lymphoma
  Most NHL's are of B cell origin (85%)
• See Also:
  White blood cell disorders
• Associated With:
  MALT gastric lymphoma
  Immunosuppression
• Differential Diagnosis:
  Hodgkin's lymphoma (mediastinal lymphadenopathy)