Pathogenesis believed to involve a 'pseudo-allergic reaction' that is an exaggerated release of vasoactive and inflammatory mediators in susceptible individuals
Accumulation of leukotrienes and changed prostaglandin/leukotriene balance triggers characteristic reaction (bronchoconstriction, polyp formation)
History / PE:
Recent use of ASA
Asthma Chronic rhinosinusitis with nasal polyposis
Bronchospasm/nasal congestion
Bland tasting food (from anosmia)
Treatment:
Avoidance of NSAIDs Leukotriene receptor antagonists (eg. montelukast, zileuton)
Surgery for temporary relief ( polyps grow back)
Medical management of underlying etiology
