Chronic kidney disease CKD

• History / PE:
  Asymptotic until GFR < 30
  Ascites
  Pallor, fatigue
  AMS
• Diagnosis:
  Azotemia (increase in BUN and creatinine)
  Fluid retention
  Metabolic acidosis
  Anemia of chronic disease (decrease EPO production)
  Hypocalcemia , hyperphosphatemia
• Treatment:
  ACEIs/ARB
  HTN control
  Hemodialysis
• Complications:
  Coagulopathic, abnormal hemostasis (from platelet dysfunction)-treat with DDAVP
  Uremic pericarditis (hemodialize immediately)
• Associated With:
  Diabetes
  Hypertension
  Glomerulonephritis