Chronic myelogenous leukemia CML

• Facts:
  Clonal expansion of myeloid progenitor cells
  Affects middle aged patients
  DIvided into 3 phases
• History / PE:
  Splenomegaly
  RUQ pain
  Constitutional symptoms
• Diagnosis:
  Philadelphia chromosome t(9,22)
  BCR-ABL translocation
  Low leukocyte alkaline phosphatase (LAP)
• Treatment:
  Imatinib (gleevac, BCR-ABL tyrosine kinase inhibitor)
• Complications:
  May progress to acute myelogenous leukemia (AML)
• See Also:
  White blood cell disorders
• Differential Diagnosis:
  Leukemoid reaction (elevated LAP)
  Paroxysmal nocturnal hemoglobinuria (low LAP)